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Association Between Aortic Vascular Inflammation by PET/CT and Aortic Distensibility by MRI in Psoriasis Open Access

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Globally, 18 million people die from cardiovascular disease (CVD) annually, making it the leading cause of morbidity and mortality worldwide. In recent years, inflammation has been established as a key cause of CVD, but the effects of anti-inflammatory treatment on cardiovascular (CV) risk remains poorly understood. Psoriasis (PSO), a chronic inflammatory skin disease associated with increased CV events, provides an ideal clinical model to study the role of inflammation in CV disease. Aortic vascular inflammation (VI) by [18F]-fluorodeoxyglucose (FDG) PET/CT as well as aortic distensibility (AD) by MRI, are important markers of subclinical CV disease and have been shown to predict future CV events. Following subclinical markers, such as AD, enables physicians to make judicious treatment decisions before CV events such as stroke, myocardial infarction, or angina occur. Our study demonstrates a novel association between VI and AD in patients with chronic inflammatory disease.

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