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Differential Gene Expression in Primary Human CD4+ T Cells Induced by HIV Nef Open Access

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The Nef protein is responsible for T-cell activation and formation of a persistent state of infection in HIV disease. Findings from the Sydney Blood Bank Cohort and other case studies indicate that individuals infected with a variant of HIV containing a defective nef gene displayed a slower development to AIDS compared to individuals infected with wild-type HIV. Our study investigates the role of the Nef protein on cellular gene transcription in infected primary CD4+ T cells with the goal of understanding how HIV Nef promotes viral replication and subsequent cellular pathology.

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