Analogs of Natural Product FR900098 as Small Molecule Inhibitors for the Methylerythritol Phosphate (MEP) Pathway in Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf)

Abstract of ThesisAnalogs of Natural Product FR900098 as Small Molecule Inhibitors for the Methyl Erythritol Phosphate (MEP) Pathway in Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf)Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf) are very prevalent and deadly species affecting millions of people’s lives while causing lots of infection-related deaths every year. Effective drugs discovered in the past are now facing great challenges such as multi-drug resistance. Due to the urgent need to discover efficacious molecules that can kill Mtb and Pf through novel modes of actions, we have designed, synthesized, and tested a series of analogs of a natural product, FR900098. These compounds were synthesized aiming to block 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), the second step of the methyl erythritol 4-phosphate (MEP) pathway. Out of the eighteen molecules in this series, SRW-61 has shown the best Pf whole cell inhibition.

Author

• Wang, Ruiqin

Language

• en

Keyword

• Mycobacterium tuberculosis
• FR900098
• Analog
• Fosmidomycin
• Plasmodium falciparum

Date created

• 2018

Type of Work

• Master's Thesis

License

• All rights reserved

Rights statement

• In Copyright

GW Unit

• Chemistry

Degree

• M.S.

Advisor

• Dowd, Cynthia S

Committee Member(s)

• King, Michael M
• Dowd, Cynthia S

Persistent URL

•  https://scholarspace.library.gwu.edu/etd/9c67wn223