Characterization of GPR84 During Injury-Induced Inflammation

The expression, activation and function of G-Protein Coupled Receptor 84 (GPR84) can modulate macrophage function during inflammation [27]. GPR84 ligands are known to direct inflammation [12, 31] and influence myeloid lineage infiltration and recruitment [25]. However, little is known about the mechanism by which these ligands signal through GPR84 to regulate inflammatory responses—especially during injury responses in the skin. Using immunofluorescence staining and flow cytometry, qualitative and quantitative information was attained on the receptor distribution and its ligand’s contribution to wound inflammation. Understanding and inducing robust and efficient early inflammation could be the key to promoting the proper downstream progression of the wound healing process. This study focuses on the mechanism by which immune and non-immune cell receptor expression and ligand presence work to facilitate wound inflammation. Outcomes from this work serve to implicate GPR84 directly to wound inflammation, and thus providing the foundation for future studies to develop GPR84-targeted therapies to enhance efficient wound healing and treat impaired wound healing.

Author

• Babirye, Najuma Sharon

Language

• en

Keyword

• GPR84
• Inflammation
• Wound Healing
• Skin
• MCFA
• Diabetes

Date created

• 2021

Type of Work

• Master's Thesis

License

• All rights reserved

Rights statement

• In Copyright

GW Unit

• Bioinformatics and Molecular Biochemistry

Degree

• M.S.

Advisor

• Shook, Brett A

Committee Member(s)

• Villagra, Alejandro

Persistent URL

•  https://scholarspace.library.gwu.edu/etd/7h149q61j