Advanced Multiparametric Cardiac Bio-interfaces: Ex Vivo and In Vivo Approaches
Open Access DepositedThis dissertation, titled "Advanced Multiparametric Cardiac Bio-interfaces: Ex Vivo and In Vivo Approaches," explores the development and application of innovative bio-interfacing technologies for cardiac research. The study aims to advance the tools available for understanding and treating cardiac pathologies by introducing multiparametric bio-electronic devices that integrate electrophysiology with opto-physiology. Modern technological advancements form the basis of our current capabilities in cardiac research, and this work builds upon these by developing soft, flexible, and transparent high-definition arrays capable of both actuation and recording. These devices have been tested in both ex vivo and in vivo models, demonstrating their potential for precise spatiotemporal control and mapping of cardiac activity. Additionally, a wireless, implantable pacemaker validated in freely moving, fully conscious optogenetic mouse models showcase the potential for chronic in vivo applications. Further, the dissertation investigates a continuous, non-invasive approach to monitoring heart failure using new reagentless sensor technology validated in unique heart failure models. The research highlights the engineering and biological insights gained, emphasizing these advanced bio-interfaces clinical relevance and future applications. The findings demonstrate the potential of multiparametric bio-electronic devices to revolutionize cardiac research and therapy, enabling high-resolution mapping and precise control of cardiac functions. This paves the way for new therapeutic strategies and enhances our understanding of cardiac physiology and pathophysiology.
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