Building Curation Filters for BCO and Adapting the BCO Framework for Biocuration
Open AccessBiomedical research is becoming more interdisciplinary, and data sets are becoming increasingly large and complex. Many current methods in research (omics-type analyses) generate large quantities of data, and the internet generally makes access easy. However, ensuring quality and standardization of data usually requires more effort. BioCompute is a standardized method of communicating bioinformatic workflow information or an analysis pipeline. An instance of BioCompute standard is known as BioCompute Object (BCO). Biocuration involves adding value to biomedical data by the processes of standardization, quality control and information transferring (also known as data annotation). It enhances data interoperability and consistency, and is critical in translating biomedical data into scientific discovery. This research work is focused on creating curation filters for BCOs and adapting the BCO framework for biocuration. This study looks into the feasibility of creating curation filters, which will help to ensure that BCOs have high quality. Also, since the process of biocuration can be very detailed and highly complex with multiple steps, adapting a BCO framework for biocuration will ensure standardization of the biocuration process, making BioCompute a perfect fit for biocuration. In order to carry out this research, multiple database and knowledgebase that undergoes curation were studied in detail, this includes; Bgee, UniProt, SGD among others. Finally, based on the knowledge gathered from the process of biocuration, filters and steps for curation was applied to some existing BCOs. In this process, already built BCOs in the OncoMX and BioCompute databases were curated, with an aim of producing high quality BCOs. Based on compliance to a set of criteria and completeness of the domains, the BCOs were ranked into three levels; gold, silver and bronze. The result showed that none of the existing BCO that was curated met the gold standard. The OncoMX BCOs were on the bronze level, while those in the BCO DB were on the silver level. Suggestions were also made on ways to adapt the current BCO frame work to biocuration. However, more work needs to be done to create BCO that is specific to biocuration.
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Onyegbula_gwu_0075M_15269.pdf | 2020-09-08 | Open Access |
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