ABCA1 is an integral transmembrane protein that facilitates the transport of intracellular cholesterol and phospholipids to the extracellular acceptor ApoA-I, the process termed cholesterol efflux. HIV-1 infection impairs ABCA1-mediated cholesterol efflux and down regulates ABCA1 protein...
HIV-infected patients are at increased risk of developing atherosclerosis, in part due to an altered HDL profile exacerbated by downmodulation and impairment of ATP-Binding Cassette Transporter A1 (ABCA1) activity by the HIV-1 protein Nef. Nef has been shown to increase delivery of cholesterol to...
HIV-infected patients are at increased risk of developing atherosclerosis, in part due to downmodulation and impairment of activity of the ATP-Binding Cassette A1 (ABCA1) cholesterol transporter by the HIV-1 protein Nef. Targeting of cholesterol to lipid rafts, regions where HIV assembles and...