Significant advances in the field of cancer immunotherapy have allowed for disease remission and improved quality of life for subsets of patients. The therapeutic potential of autologous ex vivo expanded natural killer (NK) cells to treat patients with hematological malignancies is currently...
The nucleolus within eukaryotic nuclei is formed from ribosomal DNA (rDNA) regions of acrocentric chromosomes 13, 14, 15, 21 and 22 in humans. In addition to ribosome biogenesis, the nucleolus has been shown to be important in mRNA splicing, DNA damage responses, and RNA metabolism. Nucleoli...
Introduction/Background: Ion distribution between the extracellular, cytoplasmic, and organellar spaces creates membrane potentials which drive many of life’s processes. This bioelectric membrane potential, driven by ion channel and pump activity, can be harnessed to allow or prevent entry of...
Developmental arrest is an important and common feature
of nematode development. Many parasitic and non-parasitic nematodes have
arrested third stage larvae (L3), or dauers, that may be either obligate or
facultative stages in the life cycle. In addition, the non-parasitic...
Immune system comprises of many cells and processes that together protect the host against diseases. It is equipped with unique features, including the ability of distinguishing between self and non-self entities, high sensitivity to invading antigens, response in a range of time-scales, and the...