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Filtering by: Degree Ph.D. Remove constraint Degree: Ph.D. GW Unit Biomedical Sciences Remove constraint GW Unit: Biomedical Sciences Type of Work Thesis or Dissertation Remove constraint Type of Work: Thesis or Dissertation

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Identifying novel mechanisms of melanoma metastasis through embryonic melanoblast transcriptome analysis

Description:

The enhanced ability of melanoma cells to metastasize is reminiscent of the innate propensity of melanoblasts to migrate to distant sites during embryonic development - from the neural crest to their eventual niche in the skin. Once transformed, melanoma cells mimic migratory and growth...

Author:

Mishra, Pravin J.

Keyword:

cancer, metafetal, Melanoma, mek/erk, Metastasis, and KDELR3

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Merlino, Glenn and Lee, Norman

Committee Member(s):

Pavan, William, Wakefield, Lalage, Kumar, Ajit, and Noonan, Frances

Resource Type:

Thesis or Dissertation
Studies on SLAM Family member Ly108, A Receptor involved in Thymocyte Development and Autoimmunity

Description:

Ly108 is a member of the SLAM family of receptors, which are self-ligands and are expressed on a variety of hematopoietic cells with especially high levels on developing thymocytes. SLAM receptors signal through SAP, an SH2-domain containing adaptor protein that functions by recruiting Src family...

Author:

Dutta, Mala

Keyword:

Autoimmunity, SAP, Thymocyte, SLAM family, Ly108, and SLAMf6

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Leitenberg, David and Schwartzberg, Pamela L

Committee Member(s):

Samelson, Lawrence, Varma, Rajat, Lipkowitz, Stanley, and Vukmanovic, Stanislav

Resource Type:

Thesis or Dissertation
T cell Migration and Target-Killing after a Potent Stimulation

Description:

It has been suggested that anti-tumor T cells specifically traffic to the tumor site where they effect tumor destruction. Furthermore, non-mutated tissue differentiation antigens expressed by tumors are attractive targets for cancer immunotherapy, but the consequences of a highly effective...

Author:

Palmer, Douglas

Keyword:

T cell, immune, tumor, migration, interferon, and autoimmunity

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Leitenberg, David and Restifo, Nicholas P

Committee Member(s):

Hurwitz, Andrew, Radoja, Sasa, Vukmanovic, Stanislav, and Morgan, Richard

Resource Type:

Thesis or Dissertation
The Role of ABCA1 in HIV-1 Infectivity

Description:

ABCA1 is an integral transmembrane protein that facilitates the transport of intracellular cholesterol and phospholipids to the extracellular acceptor ApoA-I, the process termed cholesterol efflux. HIV-1 infection impairs ABCA1-mediated cholesterol efflux and down regulates ABCA1 protein...

Author:

Grant, Angela Marie

Keyword:

Antiretroviral, Atherosclerosis, ABCA1, HIV, and Nef

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Bukrinsky, Michael I

Committee Member(s):

Leitenberg, David, McCaffrey, Timothy, Doebel, Hartmut, and Kumar, Ajit

Resource Type:

Thesis or Dissertation
Identification and Characterization of Putative Secreted Proteins from the Adult-Stage Hookworm, Ancylostoma caninum

Description:

Secretions from the adult-stage hookworm that mediate the host-parasite interactions have been partially identified. The proteins injected into the host during hookworm parasitism are unknown. We hypothesize that the hookworm secretions potentially injected into the host are found in the anterior...

Author:

Gindin, Mariel

Keyword:

host-parasite interactions, hookworm, transcriptome, tissue metalloprotease inhibitor, biochemical characterization, AcTMP1, and secreted proteins

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Valenzuela, Jesus G. and Hotez, Peter J.

Committee Member(s):

Brindley, Paul, Mitre, Edward, Zhan, Bin, and Bethony, Jeffrey

Resource Type:

Thesis or Dissertation
Dissecting the Molecular Mechanism of TLX1-mediated T-cell Acute Lymphoblastic Leukemia Development Using an In Vitro Immortalization Model

Description:

Inappropriate activation of the T-cell leukemia homeobox 1 (TLX1) gene by chromosomal translocation is a recurrent event in human T-cell acute lymphoblastic leukemia (T-ALL). Enforced expression of TLX1 in murine hematopoietic progenitor cells using a conventional retroviral vector yields...

Author:

Renn, Lynnsey Ann Zweier

Keyword:

Hematopoiesis, Immortalization, Leukemia, Oncogene, Stem cell, and TLX1

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Hawley, Robert G

Committee Member(s):

Leitenberg, David, McCaffrey, Timothy A, Moody, Sally A, and Lee, Norman H

Resource Type:

Thesis or Dissertation
Efficacy of Glucocorticoids in Muscular Dystrophy: Signaling, Hormonal Activities, and Muscle Inflammation

Description:

EFFICACY OF GLUCOCORTICOIDS IN MUSCULAR DYSTROPHY: SIGNALING, HORMONAL ACTIVITES AND MUSCLE INFLAMMATIONThe muscular dystrophies are a group of progressive muscle wasting disorders that currently have limited treatment options. The only indications are glucocorticoids, which are a class of...

Author:

Baudy, Andreas Reinhardt

Keyword:

Cathepsin B, 11 analogues, Live optical imaging, Delta-9, NF-kappa B, Duchenne muscular dystrophy, and Glucocorticoids

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Hoffman, Eric and Nagaraju, Kanneboyina

Committee Member(s):

Perry, David, Constant, Stephanie, Van Den Anker, John, and Hamad, Abdu

Resource Type:

Thesis or Dissertation
The Role of Lactoferrin in Breast Cancer Progression

Description:

Triple-negative breast cancer is characterized by loss of ER alpha, PR and HER2 receptors and hence, lack of responsiveness to therapies targeting these receptors. However, the nature of endogenous molecules/pathways that might be responsible for the loss of three therapeutic receptor targets and...

Author:

Ha, Ngoc-Han

Keyword:

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Kumar, Rakesh

Committee Member(s):

Dimri, Goberdhan, Levine, Paul, Lee, Norman H, Kim, Jeong-Ho, and Schwartz, Arnold

Resource Type:

Thesis or Dissertation
Role of Oxytocin Neurons in Obstructive Sleep Apnea Mediated Cardiovascular Disease

Description:

Recent work has shown oxytocin (OXT), a neuropeptide released from parvocellular neurons in the paraventricular nucleus of the hypothalamus (PVN), could be cardioprotective by exciting parasympathetic cardiac vagal neurons (CVNs) in the brainstem and reducing cardiovascular responses to stress....

Author:

Jameson, Heather Sherbs

Keyword:

Paraventricular Nucleus of the Hypothalamus, DREADDs, Oxytocin, and Hypertension

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Mendelowitz, David

Committee Member(s):

Werling, Linda, Kennedy, Katherine, Yarbrough, Tracy, and Marvar, Paul

Resource Type:

Thesis or Dissertation
Inhibition of Tumor Progression by Inhibition of Ganglioside Biosynthesis: Models and Mechanisms

Description:

Gangliosides are complex sphingolipids containing polar head groups, located primarily in cell membranes. They have long been recognized as sites of biological recognition and are involved in complex signal transduction processes, cell proliferation, differentiation, adhesion and apoptosis. Thus,...

Author:

Weiss, Michael

Keyword:

Apoptosis, GM3 Synthase Inhibition, Gangliosides, Neuroblastoma, Cancer, and Melanoma

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Ladisch, Stephan K

Committee Member(s):

Noonan, Frances P, Radoja, Sasa, Kumar, Ajit, and Colberg-Poley, Anamaris

Resource Type:

Thesis or Dissertation
Molecular Analysis of M3 Receptor Dimerization

Description:

G protein-coupled receptors (GPCRs) make up the largest class of cell surface receptors in mammals. Although historically considered to exist and function as monomeric units, GPCRs are now known to form dimers and/or oligomeric arrays both in vitro and in vivo. Class A receptors comprise the...

Author:

McMillin, Sara

Keyword:

GPCR and Dimerization

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Wess, Jürgen and Hu, Valerie W

Committee Member(s):

Weinstein, Lee S, Lakshman, Raj, Jacobson, Kenneth A, and Goldstein, Allan L

Resource Type:

Thesis or Dissertation
The role of the Wiskott-Aldrich Syndrome protein in regulating T cell programmed cell death mechanisms and implications for autoimmunity in the Wiskott-Aldrich Syndrome

Description:

The development of autoimmunity in the setting of immunodeficiency has been a paradoxical observation. Many primary immunodeficiency diseases (PIDDs) are associated with autoimmunity. Wiskott-Aldrich Syndrome (WAS), a PIDD caused by defects in the Wiskott-Aldrich Syndrome protein (WASp), has an...

Author:

Marjanovic, Sophia Y.

Keyword:

FasL, Wiskott-Aldrich Syndrome protein, microvesicles, Wiskott-Aldrich Syndrome, CD4+ T cell, and CD8+ T cell

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Leitenberg, David and Siegel, Richard

Committee Member(s):

McCaffrey, Timothy, Khan, Imitiaz, Candotti, Fabio, and Schwartzberg, Pamela

Resource Type:

Thesis or Dissertation
Molecular Basis of Paradoxical Muscle Hypertrophy in Dystrophin-Deficient Muscle

Description:

Duchenne muscular dystrophy and the genetically analogous canine condition, golden retriever muscular dystrophy (GRMD), show variable involvement of specific muscle groups within an affected individual. The sartorius muscle in Duchenne boys and the orthologous cranial sartorius (CS) in GRMD dogs...

Author:

Nghiem, Peter Phuong

Keyword:

Hypertrophy, Dystrophy, Dog, Myostatin, Osteopontin, and Muscle

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Hoffman, Eric P

Committee Member(s):

Nagaraju, Kanneyboyina, Nepote, Kathy, Kornegay, Joe N, and Lee, Norman H

Resource Type:

Thesis or Dissertation
Characterization of heterogeneity among individual neural precursor subpopulations in the embryonic mouse ventricular zone

Description:

The degree of cellular heterogeneity in the rodent neocortical ventricular zone (VZ) has been a source of contention among developmental neurobiologists for decades. The widely-held hypothesis that this germinal compartment contains a single, multipotent population of neural precursor cells...

Author:

Stancik, Elizabeth Kathryn

Keyword:

short neural precursor, ventricular zone, heterogeneity, mouse, and radial glial cell

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Haydar, Tarik F and Chiaramello, Anne

Committee Member(s):

Corbin, Joshua, Gaiano, Nicholas, Moody, Sally A, and Chiappinelli, Vincent A

Resource Type:

Thesis or Dissertation
The role of extracellular cyclophilins in chronic allergic asthma

Description:

Allergic asthma is characterized by acute influxes of pro-inflammatory leukocytes in response to allergen stimulation, followed by quiescent (chronic) periods between allergen challenges in which sustained low-level inflammation is observed. These chronic phases of disease are thought to be...

Author:

Stemmy, Erik Joseph

Keyword:

cyclophilins, NIM811, and chronic asthma

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Constant, Stephanie L

Committee Member(s):

Ceryak, Susan, Freishtat, Robert J, Noonan, Frances, and Nagaraju, Kanneboyina

Resource Type:

Thesis or Dissertation
Understanding ER-to-Mitochondria trafficking of proteins using human cytomegalovirus UL37 proteins

Description:

While precise protein sorting to cellular compartments can be directed through the ER and trans-Golgi networks, mitochondrial proteins curiously avoid this secretory pathway machinery entirely. Typically, nuclear-encoded mitochondrial proteins derive from mRNA translated on cytosolic ribosomes,...

Author:

Williamson, Chad Douglas

Keyword:

mitochondria-associated membranes, UL37x1, MAM, protein trafficking, HCMV, and vMIA

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Colberg-Poley, Anamaris M

Committee Member(s):

Donaldson, Julie G, Hu, Valerie, Rose, Mary C, and Youle, Richard

Resource Type:

Thesis or Dissertation
GENETIC FACTORS THAT ALTER THE PHARMACODYNAMICS OF ANTINEOPLASTIC AGENTS INDEPENDENT OF ALTERATIONS IN PLASMA PHARMACOKINETICS

Description:

Most anticancer agents are inherently toxic. The toxicity of these drugs is designed to target and kill specific populations of rapidly proliferating abnormal cells in tumors. The therapeutic index of anticancer drugs is maximized when these agents have the desired mechanism of action within...

Author:

Sissung, Tristan Michael

Keyword:

docetaxel, CYP1B1, pharmacogentics, paclitaxel, ABCB1, and romidepsin

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Figg, William D and Bouscarel, Bernard

Committee Member(s):

O'Brien, Travis, McCaffrey, Timothy, Deeken, John F, and Aragon-Ching, Jeanny

Resource Type:

Thesis or Dissertation
Analyzing Comparative Sequence Data to Understand Genome Function and Evolution

Description:

The ever-accelerating production of genome sequence from numerous species is providing new opportunities to examine evolution and evolutionary processes. My thesis work aimed to explore applications of comparative genome sequence datasets. As a first step we developed a computational method...

Author:

Prasad, Arjun Balmiki

Keyword:

comparative genomics, incongruence, conservation, mammal, and phylogenetics

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Green, Eric D

Committee Member(s):

Fu, Sidney, Pavan, William J, Mullikin, James C, and Allard, Marc W

Resource Type:

Thesis or Dissertation
Characterization of the Hookworm FOXO Transcription Factor DAF-16 and its Target Genes

Description:

AbstractHookworm disease is an intestinal parasitic disease of humans and animals. It continues to rank among the most important neglected tropical diseases. Blood loss resulting from heavy hookworm infections has devastating impacts for children, pregnant women, and the elderly. As do many...

Author:

Gao, Xin

Keyword:

response elements, hookworm, target gene, and FOXO/DAF-16

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Hawdon, John M

Committee Member(s):

Brindley, Paul, Ceryak, Susan, Fu, Sydney, and Mitreva, Makedonka

Resource Type:

Thesis or Dissertation
CD8 T cell dysfunction during chronic toxoplasmosis

Description:

Abstract of DissertationCD8 T cell Dysfunction during Chronic Toxoplasmosis Toxoplasmic encephalitis (TE) from reactivation of chronic Toxoplasma infection is major cause of morbidity and mortality in HIV infected Toxoplasma seropositive patients. Hence understanding the mechanisms responsible...

Author:

Bhadra, Rajarshi

Keyword:

parasite, PD-1, Toxoplasma, exhaustion, CD8, and CD40

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Khan, Imtiaz A

Committee Member(s):

Leitenberg, David, Eleftherianos, Ioannis, Radoja, Sasa, and Vukmanovic, Stanislav

Resource Type:

Thesis or Dissertation

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