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Filtering by: Author Chatterjee Bhowmick, Diti GW Unit Biochemistry & Systems Biology

The molecular mechanisms of stress-induced amylin turnover in pancreatic beta cell

Description:

Islet amyloid polypeptide (IAPP) or amylin is a pancreatic hormone produced and co-secreted with insulin from pancreatic islet β-cells that exerts local and system effects in the human body. The human form is a highly amyloidogenic and pathogenic due to its intrinsic property to aggregate in the...

Author:

Chatterjee Bhowmick, Diti

Keyword:

transcription, amylin, Islet amyloid polypeptide, protein trafficking, proteasome, and Type 2 diabetes mellitus

GW Unit:

Biochemistry & Systems Biology

Degree:

Ph.D.

Advisor:

Chiaramello, Anne and Jeremic, Aleksandar M

Committee Member(s):

Tzatsos, Alexandros, Donaldson, Robert P, Donaldson, Julie G, and O’Halloran, Damien

Resource Type:

Thesis or Dissertation