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Filtering by: Committee Member Wakefield, Lalage

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A Novel Rnaseh2c-Immune Response Axis in Breast Cancer Alters Tumor Progression and Metastasis

Description:

Breast cancer is the second leading cause of cancer-related deaths in women in the United States. Despite 98% survival for patients with localized disease, current therapies are largely ineffective against metastatic disease, reducing survival to 25%. Thus, a better understanding of the...

Author:

Deasy, Sarah K

Keyword:

Immune Response, Rnaseh2c, Breast Cancer, and Metastasis

GW Unit:

Molecular Medicine

Degree:

Ph.D.

Advisor:

Lee, Norman and Hunter, Kent

Committee Member(s):

Leitenberg, David and Wakefield, Lalage

Resource Type:

Thesis or Dissertation
Identifying novel mechanisms of melanoma metastasis through embryonic melanoblast transcriptome analysis

Description:

The enhanced ability of melanoma cells to metastasize is reminiscent of the innate propensity of melanoblasts to migrate to distant sites during embryonic development - from the neural crest to their eventual niche in the skin. Once transformed, melanoma cells mimic migratory and growth...

Author:

Mishra, Pravin J.

Keyword:

mek/erk, metafetal, Melanoma, KDELR3, cancer, and Metastasis

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Lee, Norman and Merlino, Glenn

Committee Member(s):

Pavan, William, Wakefield, Lalage, Kumar, Ajit, and Noonan, Frances

Resource Type:

Thesis or Dissertation