Index Catalog // GW ScholarSpace

Start Over

Filtering by: Committee Member Wakefield, Lalage

A Novel Rnaseh2c-Immune Response Axis in Breast Cancer Alters Tumor Progression and Metastasis

Description:

Breast cancer is the second leading cause of cancer-related deaths in women in the United States. Despite 98% survival for patients with localized disease, current therapies are largely ineffective against metastatic disease, reducing survival to 25%. Thus, a better understanding of the...

Author:

Deasy, Sarah K

Keyword:

Breast Cancer, Metastasis, Immune Response, and Rnaseh2c

GW Unit:

Molecular Medicine

Degree:

Ph.D.

Advisor:

Lee, Norman and Hunter, Kent

Committee Member(s):

Wakefield, Lalage and Leitenberg, David

Resource Type:

Thesis or Dissertation
Identifying novel mechanisms of melanoma metastasis through embryonic melanoblast transcriptome analysis

Description:

The enhanced ability of melanoma cells to metastasize is reminiscent of the innate propensity of melanoblasts to migrate to distant sites during embryonic development - from the neural crest to their eventual niche in the skin. Once transformed, melanoma cells mimic migratory and growth...

Author:

Mishra, Pravin J.

Keyword:

cancer, Melanoma, Metastasis, mek/erk, KDELR3, and metafetal

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Lee, Norman and Merlino, Glenn

Committee Member(s):

Wakefield, Lalage, Pavan, William, Noonan, Frances, and Kumar, Ajit

Resource Type:

Thesis or Dissertation