Breast cancer is the second leading cause of cancer-related deaths in women in the United States. Despite 98% survival for patients with localized disease, current therapies are largely ineffective against metastatic disease, reducing survival to 25%. Thus, a better understanding of the...
The enhanced ability of melanoma cells to metastasize is reminiscent of the innate propensity of melanoblasts to migrate to distant sites during embryonic development - from the neural crest to their eventual niche in the skin. Once transformed, melanoma cells mimic migratory and growth...