Index Catalog // GW ScholarSpace

Description:: Acute myeloid leukemias (AML) are a group of cancers of the myeloid line of blood cells that arise out of the bone marrow, progress rapidly, and interfere with the production of normal immune cells. Most AML patients who achieve a remission with standard cytotoxic chemotherapy will go on to...
Author:: Goswami, Meghali
Keyword:: irAE, B cell, AML, T cell, PD-1, and immunotherapy
GW Unit:: Molecular Medicine
Degree:: Ph.D.
Advisor:: Lee, Norman and Hourigan, Christopher
Committee Member(s):: Chiappinelli, Katherine, Barrett, John, Villagra, Alejandro, and Boritz, Eli
Resource Type:: Thesis or Dissertation

Description:: Mutations in TP53 occur in ~10-15% of patients with AML and are associated with an erythroid phenotype, mutual exclusivity with recurrent drivers, and a poor prognosis. Molecular heterogeneity and the lack of a physiological relevant mouse model have resulted in a failure to understand the...
Author:: Lap, Coen Johannes
Keyword:: Leukemia, AML, TP53, Mouse, Erythroid, and BAP1
GW Unit:: Molecular Medicine
Degree:: Ph.D.
Advisor:: Tzatsos, Alexandros and Leitenberg, David
Committee Member(s):: Chiappinelli, Katherine, Villagra, Alejandro, and Hawley, Robert
Resource Type:: Thesis or Dissertation

Description:: The histone deacetylase 6 (HDAC6), which belongs to class IIb family of HDACs is known to play a role in different cellular processes, involved in the pathogenesis of cancer and immune regulation. Recently, we found that treatment of cancer cells with HDAC6 inhibitors (HDAC6is) lead to an...
Author:: John Ephrame, Sophiya
Keyword:: Melanoma, HDAC6, BRAF-resistance, Nexturastat A, Pathways, and MITF
GW Unit:: Biological Sciences
Degree:: M.S.
Advisor:: Villagra, Alejandro
Committee Member(s):: Villagra, Alejandro and Vanderhoek, Jack
Resource Type:: Thesis or Dissertation

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