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Filtering by: Advisor Vortmeyer, Alexander O Committee Member MacDonald, Tobey J Degree Ph.D. Keyword VHL

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Effects of von Hippel-Lindau (VHL) Gene Deficiency on the Human Central Nervous System

Description:

Von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary cancer disorder caused by a germline mutation in the VHL tumor suppressor gene. Loss of the wild-type allele results in VHL deficiency and subsequent tumor formation. One common tumor in VHL patients is the cerebellar...

Author:

Shively, Sharon Baughman

Keyword:

PAX2, cerebellum, hemangioblastoma, HIF, development, and VHL

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Vortmeyer, Alexander O and Kennedy, Katherine A

Committee Member(s):

Schwartz, Arnold M, Merrill, Marsha J, Chiaramello, Anne E, and MacDonald, Tobey J

Resource Type:

Thesis or Dissertation