Index Catalog // GW ScholarSpace

Description:: The Signal Transducer and Activator of Transcription 3 (STAT3), the key protein in the JAK-STAT3 pathway, regulates the expression of several genes involved in cell proliferation, immune responses, and other essential cellular functions. Additionally, STAT3 impaired or constitutive activity has...
Author:: Zevallos Delgado, Christian
Keyword:: STAT3, HDAC6, Molecular Dynamics, HDAC6 inhibitors, and PP2A
GW Unit:: Bioinformatics and Molecular Biochemistry
Degree:: M.S.
Advisor:: Villagra, Alejandro and Hepp Castro, Matías Ignacio
Resource Type:: Thesis or Dissertation

Description:: Melanoma is the deadliest type of skin cancer, and it is estimated that 100,000 people will be diagnosed in 2020. BRAFV600E mutation is found in approximately 50% of melanoma cases. Although targeted therapy with BRAF inhibitor (BRAFi), vemurafenib has shown promising results, some patients do...
Author:: Murtadha, Fatimah
Keyword:
GW Unit:: Biochemistry & Systems Biology
Degree:: M.S.
Advisor:: Villagra, Alejandro and Vanderhoek, Jack
Resource Type:: Thesis or Dissertation

Description:: The histone deacetylase 6 (HDAC6), which belongs to class IIb family of HDACs is known to play a role in different cellular processes, involved in the pathogenesis of cancer and immune regulation. Recently, we found that treatment of cancer cells with HDAC6 inhibitors (HDAC6is) lead to an...
Author:: John Ephrame, Sophiya
Keyword:: Melanoma, HDAC6, BRAF-resistance, Nexturastat A, Pathways, and MITF
GW Unit:: Biological Sciences
Degree:: M.S.
Advisor:: Villagra, Alejandro
Committee Member(s):: Villagra, Alejandro and Vanderhoek, Jack
Resource Type:: Thesis or Dissertation

Description:: Previous gene expression studies in melanoma have revealed that several signaling pathways are modulated by specific histone deacetylases (HDAC). Among them, HDAC6 has been shown to control antigen presentation and other immunomodulatory functions. WM164 Non-target (NT) and WM164 HDAC6 Knock down...
Author:: Vembu, Prathima
Keyword:: Melanoma, HDAC6, and Temporal Gene expression
GW Unit:: Biological Sciences
Degree:: M.S.
Advisor:: Villagra, Alejandro
Committee Member(s):: Horvath, Anelia
Resource Type:: Thesis or Dissertation

Limit your search