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Filtering by: Advisor Villagra, Alejandro Degree M.S.

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Analysis of the Role of HDAC6 on MITF Pathway, in the Pathogenesis of Melanoma

Description:

The histone deacetylase 6 (HDAC6), which belongs to class IIb family of HDACs is known to play a role in different cellular processes, involved in the pathogenesis of cancer and immune regulation. Recently, we found that treatment of cancer cells with HDAC6 inhibitors (HDAC6is) lead to an...

Author:

John Ephrame, Sophiya

Keyword:

Nexturastat A, Pathways, BRAF-resistance, HDAC6, MITF, and Melanoma

GW Unit:

Biological Sciences

Degree:

M.S.

Advisor:

Villagra, Alejandro

Committee Member(s):

Vanderhoek, Jack and Villagra, Alejandro

Resource Type:

Thesis or Dissertation
Temporal regulation of cytokine-mediated gene expression changes upon genetic intervention of Histone deacetylase 6

Description:

Previous gene expression studies in melanoma have revealed that several signaling pathways are modulated by specific histone deacetylases (HDAC). Among them, HDAC6 has been shown to control antigen presentation and other immunomodulatory functions. WM164 Non-target (NT) and WM164 HDAC6 Knock down...

Author:

Vembu, Prathima

Keyword:

HDAC6, Temporal Gene expression, and Melanoma

GW Unit:

Biological Sciences

Degree:

M.S.

Advisor:

Villagra, Alejandro

Committee Member(s):

Horvath, Anelia

Resource Type:

Thesis or Dissertation