Virtual memory (VM) cells exist in the steady-state in unimmunized mice as memory phenotype, antigen-specific CD8+ T cells. VM cells display phenotypic and functional similarity to antigen-driven memory cells, however they exist at vanishingly low frequencies making them challenging to isolate,...
T cell tolerance to tumor antigens is a considerable challenge to cancer immunotherapy. To study T cell tolerance to tumor antigens, our laboratory utilizes the TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model in combination with adoptive transfer of TcR transgenic T cells with...