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Filtering by: Advisor Hurwitz, Arthur A Degree Ph.D. Type of Work Thesis or Dissertation

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Provision of Antigen-Specific CD4+ T cells Prevents the Tolerization of CD8+ Tumor-Specific T cells in a Mouse Model of Prostate Cancer

Description:

T cell tolerance to tumor antigens is a considerable challenge to cancer immunotherapy. To study T cell tolerance to tumor antigens, our laboratory utilizes the TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model in combination with adoptive transfer of TcR transgenic T cells with...

Author:

Shafer-Weaver, Kimberly Ann

Keyword:

CD4+ T cells, Tumor, Cytotoxic T Lymphocyte, Prostate cancer, Immunotherapy, and Tolerance

GW Unit:

Biomedical Sciences

Degree:

Ph.D.

Advisor:

Hurwitz, Arthur A

Committee Member(s):

Leitenberg, David, Pinto, Ligia, Keller, Jonathon, Malyguine, Anatoli, and Constant, Stephanie

Resource Type:

Thesis or Dissertation
Phenotypic, Functional, and Developmental Characterization of a Mouse Model for Virtual Memory CD8+ T Cells

Description:

Virtual memory (VM) cells exist in the steady-state in unimmunized mice as memory phenotype, antigen-specific CD8+ T cells. VM cells display phenotypic and functional similarity to antigen-driven memory cells, however they exist at vanishingly low frequencies making them challenging to isolate,...

Author:

Stagliano, Katherine Roth

Keyword:

GW Unit:

Microbiology & Immunology

Degree:

Ph.D.

Advisor:

Leitenberg, David and Hurwitz, Arthur A

Committee Member(s):

Hanley, Patrick and Cruz, Conrad R

Resource Type:

Thesis or Dissertation